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KMID : 1149220090170020123
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Korean Journal of Oriental Medical Prescription
2009 Volume.17 No. 2 p.123 ~ p.132
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Protective Effect of Joo-Juk on Acetaminophen-induced Liver Damage in Mouse Model
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Kim Sung-Zoo
Kang Hyung-Sub
Shin Jae-Suk
Xie Guanghua
Huh Jin
Jang Seon-Il
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Abstract
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Acetaminophen (AP) is widely used as an over-the-counter analgesic and antipyretic drug. AP-induced hepatotoxicity is a common consequence of AP overdose and may lead to acute liver failure. In this study, we investigated the liver damage in mice using single dose (300 mg/kg) of AP and the possible protective effects of administration (50-200 mg/kg body weight) of Joo-Juk on acetaminophen-induced liver damage in mice. The alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activities were determined in the plasma of mice. The effect of Joo-Juk on lipid peroxidation product thiobarbituric reacting substances (TBARS) and some antioxidant enzymes superoxide dismutase (SOD), catalase, d-aminolevulinate dehydratase (σ-ALA-D) activities, and gluthathione peroxidase (GPx), were also evaluated in the mouse liver homogenate. AP caused liver damage as evident by statistically significant increased in plasma activities of AST and ALT. There were statistically significant losses in the activities of SOD, catalase, σ-ALA-D, and GPx and an increase in TBARS in the liver of AP-treated group compared with the control group. However, Joo-Juk was able to counteract these effects. These results suggest that Joo-juk can act as hepato-protectant against AP toxicity and is a good candidate for further evaluation as an effective chemotherapeutic agent.
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KEYWORD
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Joo-Juk, Oxidative stress, Hepatotoxicity, Antioxidant, Acetaminophen
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